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En usikkerhed ved et registerstudie som dette er Puppy, at det ikke kan blive helt klart, hvorvidt en faktor såsom smertestillende piller står bag hele den tilsyneladende effekt på blodpropper.Metadon er et naturligt opioid, som anvendes mod kroniske smerter. Midlet er meget langsomt udskilt fra kroppen igen, og bør derfor ikke anvendes ved aku

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